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This methylation profile is by now acquired in the MBL stage3 and continues to be rather steady after a while. Nonetheless, some CLL have intratumor variability in particular locations, which can alter the expression of quite a few genes and facilitate tumor evolution.71 Of Take note, this variability is larger in U-CLL than in M-CLL and it is associated with expanding amount of subclones.7,seventy one

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forty eight These translocations may well arise inside the context of complex karyo forms. The most typical rearrangements include 13q14, with multiple companions, and also the IGH locus. The genes most often rearranged with IGH are BCL2

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